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  6. 17207573

Invitrogen™ ABL1/ABL2 Polyclonal Antibody
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Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5114805

Product Code. 17207573

  • 5380.00 NOK / 100µL

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Description

Description

Antibody detects endogenous levels of total ABL1/2.

The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ABL1/ABL2
Polyclonal
Unconjugated
ABL1
AA536808; Abelson murine leukemia oncogene; Abelson murine leukemia viral (v-abl) oncogene homolog 1; Abelson murine leukemia viral (v-abl) oncogene homolog 2; abelson murine leukemia viral oncogene homolog 1; Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 1; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; Abl; ABL proto-oncogene 1, non-receptor tyrosine kinase; ABL proto-oncogene 2, non-receptor tyrosine kinase; ABL1; Abl1-related gene product; abl2; ABLL; AI325092; Arg; arg tyrosine kinase; bcr/abl; bcr/c-abl oncogene protein; c-Abl; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; c-ABL1; E430008G22Rik; JTK7; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; tyrosine kinase ARG; tyrosine-protein kinase ABL1; Tyrosine-protein kinase ABL2; tyrosine-protein kinase ARG; v-abl; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene 1; v-abl Abelson murine leukemia viral oncogene 2; v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene); v-abl Abelson murine leukemia viral oncogene homolog 1; v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
Rabbit
Affinity chromatography
RUO
11350, 11352, 25, 27
-20°C
Liquid
Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide
P00519, P00520, P42684, Q4JIM5
ABL1, ABL2
A synthesized peptide derived from human ABL1(Accession P00519), corresponding to amino acid residues R367-S417.
100 μL
Primary
Human, Mouse, Monkey
Antibody
IgG
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