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  8. T0901317, MedChemExpress

T0901317, MedChemExpress

Product Code. 16400437
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Product Code. 16400437

Brand: Medchem Express HY10626

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Description

MedChemExpress T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα. T0901317 activates FXR with an EC50 of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice.

T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα. T0901317 activates FXR with an EC50 of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice.

Specifications

Chemical Name or Material T0901317
CAS 293754-55-9
Color Off-White
Purity Grade Notes Research
Molecular Formula C17H12F9NO3S
Quantity 50 mg
Solubility Information DMSO : 100 mg/mL (207.76 mM; Need ultrasonic)
SMILES OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(N(CC(F)(F)F)S(C2=CC=CC=C2)(=O)=O)C=C1
Molecular Weight (g/mol) 481.33
Formula Weight 481.33
Percent Purity 99.8%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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