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Flumatinib mesylate, MedChemExpress

Product Code. 16491706
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Quantity:
500 mg
Unit Size:
500mg
Product Code. Quantity unitSize
16491706 500 mg 500mg
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Product Code. 16491706

Brand: Medchem Express HY13905

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Description

MedChemExpress Flumatinib (HHGV678) mesylate is an orally active and selective inhibitor of Bcr-Abl. Flumatinib mesylate inhibits c-Abl, PDGFRβ and c-Kit with IC50 values of 1.2, 307.6 and 665.5 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model.

Flumatinib (HHGV678) mesylate is an orally active and selective inhibitor of Bcr-Abl. Flumatinib mesylate inhibits c-Abl, PDGFRβ and c-Kit with IC50 values of 1.2, 307.6 and 665.5 nM, respectively. Flumatinib mesylate inhibits Bcr-Abl autophosphorylation and Stat5 and Erk1/2 phosphorylation. Flumatinib mesylate inhibits tumor growth in chronic myelogenous leukemia model.

Specifications

Chemical Name or Material Flumatinib mesylate
CAS 895519-91-2
Color Yellow
Purity Grade Notes Research
Molecular Formula C30H33F3N8O4S
Quantity 500 mg
Synonym HHGV678 mesylate
Solubility Information H2O : 50 mg/mL (75.91 mM; Need ultrasonic) ∣DMSO : 50 mg/mL (75.91 mM; Need ultrasonic)
SMILES O=C(NC1=CC(NC2=NC=CC(C3=CC=CN=C3)=N2)=C(C)N=C1)C4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4.CS(=O)(O)=O
Molecular Weight (g/mol) 658.69
Formula Weight 658.69
Percent Purity 99.73%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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