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  7. 3-Isobutyl-1-Methylxanthine, MP Biomedicals™

3-Isobutyl-1-Methylxanthine, MP Biomedicals™
BIOPHARMA

Catalog Number 11485222
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Quantity:
100 mg
250 mg
1 g
5 g
This item is not returnable. View return policy
28822-58-4
C10H14N4O2
222.25
MFCD00005584
APIXJSLKIYYUKG-UHFFFAOYSA-N
3-isobutyl-1-methylxanthine, ibmx, isobutylmethylxanthine, 1-methyl-3-isobutylxanthine, methylisobutylxanthine, 3-isobutyl-1-methyl-1h-purine-2,6 3h,7h-dione, xanthine, 3-isobutyl-1-methyl, 3-isobutyl-1-methyxanthine, 1h-purine-2,6-dione, 3,7-dihydro-1-methyl-3-2-methylpropyl, methyl-isobutylxanthine
3758
CHEBI:43253
1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
CC(C)CN1C2=C(NC=N2)C(=O)N(C)C1=O
This item is not returnable. View return policy
28822-58-4
C10H14N4O2
222.25
MFCD00005584
APIXJSLKIYYUKG-UHFFFAOYSA-N
3-isobutyl-1-methylxanthine, ibmx, isobutylmethylxanthine, 1-methyl-3-isobutylxanthine, methylisobutylxanthine, 3-isobutyl-1-methyl-1h-purine-2,6 3h,7h-dione, xanthine, 3-isobutyl-1-methyl, 3-isobutyl-1-methyxanthine, 1h-purine-2,6-dione, 3,7-dihydro-1-methyl-3-2-methylpropyl, methyl-isobutylxanthine
3758
CHEBI:43253
1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
CC(C)CN1C2=C(NC=N2)C(=O)N(C)C1=O

Description

Known as IBMX. 3-Isobutyl-1-Methylxanthine, MP Biomedicals is a potent, non-specific inhibitor of cAMP and cGMP phosphodiesterases, significantly more effective than theophylline. This inhibition activates PKA, leading to decreased proliferation, increase

A non-specific inhibitor of adenosine 3',5'-cyclic monophosphate phosphodiesterase (cAMP PDE)4, significantly more effective than theophylline. Also inhibits cGMP phosphodiesterases. IBMX inhibits cyclic nucleotide PDE with subsequent inhibition of cyclic nucleotide hydrolysis, resulting in accumulation of cyclic AMP and guanosine 3',5'-cyclic monophosphate.

  • Inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3μM)
  • Serves as an adenosine receptor antagonist
  • Inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells
  • Induces calcium release from intracellular stores in sensory neurons
  • Inhibits the growth of carcinoma cells both in vivo and in vitro in mice
Melting Point 195°C to 202°C
Quantity 100 mg
Formula Weight 222.25
Physical Form Powder
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