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Thermo Scientific™ 2'-Fluoro-iBu-G Phosphoramidite, standard grade, 28-400 finish bottle
2'-Fluoro-iBu-G CEP is a phosphoramidite containing 5' DMT and the nucleoside guanosine (G) with 2'-Fluoro protection, for use in oligonucleotide synthesis.
Brand: Thermo Scientific™ 27-1607-12
Additional Details : Weight : 0.05150kg
Description
2'-Fluoro-iBu-G CEP is a phosphoramidite containing 5' DMT and the nucleoside guanosine (G) with 2'-Fluoro protection, for use in oligonucleotide synthesis. Located in the ideal oligo position, the highly electronegative fluorine (2'-Fluoro) modification adopts a more thermodynamically stable A-form helix on hybridization to its target. Showing improved affinity and some nuclease resistance (compared to 2'-OH), the 2'-F modification has been proven useful in antisense, siRNA, and aptamer applications. The 'standard grade' marking denotes a baseline level of purity verified with analytical methods, and proven to be suitable for most oligo synthesis requirements. This product is supplied in a 30-mL amber bottle with a 28-400 finish neck style, which is compatible with most MerMade synthesizers.
Features:
• Full chemical name: 5'-O-(4,4'-Dimethoxytrityl)-N2-isobutyryl-2'-fluoroguanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
• Molecular formula: C44H53FN7O8P
• Base: G
• Base Protection: iBu
• Formula weight: 857.4 g/mol
• CAS number: 144089-97-4
• HPLC purity: >98%
• 31P NMR purity: ≥98%
Specifications
| MerMade Synthesizers | |
| Store in freezer (at or below -20°C). | |
| 2in-Fluoro modified | |
| 98% | |
| Phosphoramidite | |
| RNA |
| 2in-Fluoro-iBu-G CEP | |
| Guanosine (G) | |
| Room Temperature | |
| 0.5 g | |
| Standard | |
| Powder |