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Ilorasertib, MedChemExpress

Product Code. 16427046
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16427046 100 mg 100mg
16433027 50 mg 50mg
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Product Code. 16427046

Brand: Medchem Express HY16018

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Description

MedChemExpress Ilorasertib (ABT-348) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively.

Ilorasertib (ABT-348) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively.

Specifications

Chemical Name or Material Ilorasertib
CAS 1227939-82-3
Color Brown
Purity Grade Notes Research
Molecular Formula C25H21FN6O2S
Quantity 100 mg
Synonym ABT-348
Solubility Information DMSO : 41.67 mg/mL (85.29 mM; Need ultrasonic)
SMILES O=C(NC1=CC=CC(F)=C1)NC2=CC=C(C3=CSC4=C3C(N)=NC=C4C5=CN(CCO)N=C5)C=C2
Molecular Weight (g/mol) 488.54
Formula Weight 488.54
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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