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TREX1 Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
1611.84 NOK - 4593.76 NOK
Specifications
Antigen | TREX1 |
---|---|
Concentration | 0.35 mg/mL |
Applications | Immunoprecipitation, Western Blot |
Classification | Polyclonal |
Conjugate | Unconjugated |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
16803385
|
Proteintech
24876-1-AP-20UL |
20 μL |
1611.84 NOK
20µL |
Estimated Shipment: 06-05-2024 Log in to see stock. |
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16893375
|
Proteintech
24876-1-AP-150UL |
150 μL |
4593.76 NOK
150µL |
Estimated Shipment: 06-05-2024 Log in to see stock. |
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Description
Trex1 (ATRIP) is the major human 3′ to 5′ exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3′ to 5′ exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.Specifications
TREX1 | |
Immunoprecipitation, Western Blot | |
Unconjugated | |
Rabbit | |
Human | |
Q9NSU2 | |
11277 | |
TREX1 Fusion Protein Ag18325 | |
Primary | |
-20°C | |
TREX1 |
0.35 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
3 5 exonuclease TREX1, AGS1, AGS5, CRV, DNase III, DRN3, HERNS, TREX1 | |
TREX1 | |
IgG | |
Antigen Affinity Chromatography | |
Antibody |