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T-bet Monoclonal Antibody (eBio39D (39D, 3-9D)), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
1192.00 NOK - 3405.00 NOK
Specifications
Antigen | T-bet |
---|---|
Clone | eBio39D (39D, 3-9D), 3-9D) |
Concentration | 0.5 mg/mL |
Applications | ChIP Assay, Immunocytochemistry, Immunoprecipitation, Western Blot |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15297487
|
Affymetrix eBioscience
14-5824-80 |
25 μg |
1192.00 NOK
25µg |
Estimated Shipment: 08-05-2024 Log in to see stock. |
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15207497
|
Affymetrix eBioscience
14-5824-82 |
100 μg |
3405.00 NOK
100µg |
Estimated Shipment: 08-05-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
Description: The eBio39D monoclonal antibody reacts with mouse, rat and human T-bet. T-bet is a Th1-specific T-box transcription factor critical to the development of the Th1 CD4+ T cell lineage. This is known based on the observations that T-Bet deficient mice have impaired Th1 cell development, and that ectopic expression of T-Bet results in development skewed to the Th1 lineage. T-Bet expression is induced by the Th1 cytokine IFN-gamma, and T-Bet also regulates the expression of IFN-gamma, likely, at least in part, through the modification of DNA accessibility and histone remodeling. In addition to IFN-gamma, T-Bet is also known to regulate the expression of IL-12Rbeta and IL-2. Moreover, T-Bet plays a role in class-switch recombination in B-cells. Applications Reported: This eBio39D (39D, 3-9D) antibody has been reported for use in immunoprecipitation, and immunoblotting (WB). Applications Tested: This eBio39D (39D, 3-9D) antibody has been tested by western blot analysis of Th1-polarized mouse CD4+ T cells and can be used at 2 μg/mL as a starting dilution for western blotting. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.
T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.Specifications
T-bet | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
HGNC:11599; LOW QUALITY PROTEIN: T-box transcription factor TBX21; Tbet; T-bet; TBLYM; T-box 21; T-box expressed in T cells; T-box protein 21; T-box transcription factor 21; T-box transcription factor TBX21; TBT1; TBX21; T-cell-specific T-box transcription factor T-bet; T-PET; transcription factor TBLYM; transcription factor T-box 21 | |
Tbx21 | |
Primary | |
4° C | |
Tbx21 |
eBio39D (39D, 3-9D), 3-9D) | |
ChIP Assay, Immunocytochemistry, Immunoprecipitation, Western Blot | |
Unconjugated | |
Mouse | |
Human, Mouse, Rat | |
Q9JKD8, Q9UL17 | |
30009, 303496, 57765 | |
IgG1 | |
Affinity chromatography | |
Antibody |
For Research Use Only.