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SIGLEC H, eFluor 660, clone: eBio440c, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-0333-82

Additional Details : Weight : 0.25000kg

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Product Code. 15361860

  • 2280.00 NOK / 100µg


Estimated Shipment date
from Supplier 25-04-2019
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Description

Description

eFluor™ 660 is a replacement for Alexa Fluor™ 647. eFluor™ 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. Siglec-H, a protein exclusively found on pDC (plasmacytoid dendritic cells) or type I IFN-producing cells (IPC) in the naive mouse. Mouse IPC are typically PDCA+, CD11c+, CD11b-, B220+, and Ly-6C+, and are quick to respond to viruses. Siglec-H is a transmembrane protein of the Ig superfamily that like CD33 have been shown to bind sialic acid but lacks the characteristic cytoplasmic ITIM domain (immunoreceptor tyrosine based inhibitory motif). To overcome the lack of a cytoplasmic domain, Siglec-H associates with DAP12 thereby allowing for signal transduction. The eBio440c antibody has been shown to inhibit pDC function (inhbits IFNalpha secretion in response to CpG). It has been observed that some mouse strains (such as SJL) have higher percentages of pDCs compared to C57BL/6.
Specifications

Specifications

siglec H
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Liquid
Siglech
IgG2b, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
233274
Flow Cytometry
eBio440c
eFluor® 660
Siglech
Sialic Acid-Binding Immunoglobulin-Like Lectin H; SiglecH
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
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