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  7. (S,R,S)-AHPC-Me dihydrochloride, MedChemExpress

(S,R,S)-AHPC-Me dihydrochloride, MedChemExpress

Product Code. 16497826
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500 mg
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Product Code. 16497826

Brand: Medchem Express HY42424A

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Description

MedChemExpress (S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.

Specifications

Chemical Name or Material (S,R,S)-AHPC-Me dihydrochloride
Color Yellow
Purity Grade Notes Research
Molecular Formula C23H34Cl2N4O3S
Quantity 100 mg
Synonym VHL ligand 2 dihydrochlorideE3 ligase Ligand 1 dihydrochloride
Solubility Information H2O : 100 mg/mL (193.23 mM; Need ultrasonic) ∣DMSO : 50 mg/mL (96.62 mM; ultrasonic and warming and heat to 60°C)
SMILES N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O.Cl.Cl
Molecular Weight (g/mol) 517.51
Formula Weight 517.51
Percent Purity 98.12%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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