Invitrogen™ Human PPARD, Ligand Binding Domain, GST Tag Recombinant Protein

Description

Peroxisome Proliferator Activated Receptor delta, Ligand Binding Domain (PPAR delta-LBD) is a 59.90 kDa recombinant human protein (amino acids 165-441) expressed as a GST-tagged fusion protein in E. coli cells. PPAR delta-LBD was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies. Protein Form: Recombinant, Ligand Binding Domain

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.