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Tocris Bioscience™ Pexidartinib

Potent CSF-1R inhibitor

1587.43 NOK - 5617.56 NOK

Specifications

Chemical Name or Material N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
CAS 1029044-16-3
Target Additional RTK Inhibitors
Molecular Formula C20H15ClF3N5
Purity 98%
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Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
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Tocris Bioscience™
7590/10
10 mg
1587.43 NOK
10mg
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18706716
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Tocris Bioscience™
7590/50
50 mg
5617.56 NOK
50mg
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Estimated Shipment: 29-07-2024
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Description

Description

Pexidartinib is a potent colony-stimulating factor-1 receptor (CSF-1R) tyrosine kinase inhibitor (IC50 = 20 nM). In the B16F10 mouse melanoma model, Pexidartinib reduces the systemic and local accumulation of macrophages without affecting Gr-1+ myeloid derived suppressor cells. When combined with tumor-specific CD8 T cell immunotherapy, Pexidartinib promotes the control of tumor growth. In the BRAFV600E-driven mouse melanoma model, Pexidartinib improves the efficacy of adoptive cell therapy with reduction of TIMs and an increase in tumor-infiltrating lymphocytes and T cells. Orally bioavailable.
Specifications

Specifications

N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
Additional RTK Inhibitors
98%
1029044-16-3
C20H15ClF3N5
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