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MHC Class II I-Ab Mouse anti-Mouse, eFluor® 450, Clone: AF6-120.1, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 48-5320-80

Additional Details : Weight : 0.25000kg

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Product Code. 15361780

  • 802.00 NOK / 25µg


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Description

Description

MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II.
Specifications

Specifications

MHC Class II I-Ab
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P06342
H-2Eb, H2Eb, Ia-4, Ia4, MGC163794, MGC163796
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
AF6-120.1
eFluor® 450
H2-Ab1
Liquid
H2-Ab1
IgG2a, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
14961
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