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Tocris Bioscience™ JNJ 10198409
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Product Code. 18776356
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18776356

Brand: Tocris Bioscience™ 6976/10

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Description

Potent PDGFRα and PDGFRβ inhbitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases

JNJ 10198409 is a potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC50 values are 4.2 and 45 nM for PDGFRβ and PDGFRα, respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC50 values are 22, 100, 185 and 378 nM respectively). Displays antiproliferative activity in multiple tumor cell lines. Accelerates down regulation of fibroblast genes in reprogramming of human fibroblasts into functional cardiomyocytes, within 9C cocktail.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine
CAS 627518-40-5
Quantity 10 mg
Target PDGF Receptor Inhibitors
Molecular Formula C18H16FN3O2
Formula Weight 2273
Purity 98%
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