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IL-15 Mouse anti-Human, Functional Grade, Clone: ct2nu, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-0157-85

Additional Details : Weight : 0.01000kg

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Product Code. 15268387

  • 2305.00 NOK / 500µg


Estimated Shipment date
from Supplier 03-07-2019
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Description

Description

001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other′s activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.
Specifications

Specifications

IL-15
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
P40933
Interleukin-15, MGC9721
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Functional Assay, Neutralization
ct2nu
Functional Grade
IL15
Liquid
IL15
IgG1, kappa
500 μg
4° C
Primary
3600
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