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IL-10 Monoclonal Antibody (JES5-16E3), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

906.00 NOK - 17810.00 NOK

Specifications

Antigen IL-10
Clone JES5-16E3
Concentration 1 mg/mL
Classification Monoclonal
Conjugate Functional Grade
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15278757
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Affymetrix eBioscience
16-7101-85
500 μg
2965.00 NOK
500µg
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Estimated Shipment: 08-05-2024
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15577806
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Affymetrix eBioscience
16-7101-38
5 mg
17810.00 NOK
5mg
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Estimated Shipment: 08-05-2024
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15268757
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Affymetrix eBioscience
16-7101-81
50 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The JES5-16E3 antibody reacts with mouse interleukin-10 (IL-10). Mouse IL-10 is an ∽18 kDa factor also known as Cytokine Synthesis Inhibitory Factor (CSIF). In the mouse, Th2 cells, B1 cells, macrophages, and keratinocytes are the major cell subsets that produce IL-10. IL-10 inhibits synthesis of Th1 cytokines and proliferation of T cells, and acts as a costimulatory signal for mast cells, developing thymocytes and the Th2 response. Applications Reported: The JES5-16E3 antibody has been reported for use in capture of mouse IL-10 by ELISA and ELISPOT, intracellular staining for flow cytometric analysis, IHC, and neutralization of IL-10 bioactivity. Applications Tested: The Functional Grade purified JES5-16E3 antibody has been tested for ELISPOT capture. A suitable range of concentrations of this antibody for ELISPOT capture is 1-4 μg/mL. The JES5-16E3 antibody has been tested as the capture antibody in a sandwich ELISA for analysis of mouse interleukin-10 (IL-10) in combination with the biotinylated JES5-2A5 (13-7102) antibody for detection and recombit mouse IL-10 (14-8101) as the standard. A suitable range of concentrations of this antibody for ELISA capture is 1-4 μg/mL. A standard curve consisting of doubling dilutions of the recombit standard over the range of 4000 pg/mL - 30 pg/mL should be included in each ELISA plate. Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
Specifications

Specifications

IL-10
1 mg/mL
Functional Grade
Rat
Mouse
P18893
IgG2b κ
Affinity chromatography
Antibody
JES5-16E3
Monoclonal
Liquid
RUO
PBS with no preservative; pH 7.2
16153
Primary
4° C
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SDS
Documents

Documents

Product Certifications

For Research Use Only.