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Invitrogen™ Human TNF-alpha Recombinant Protein

Product Code. 11559051
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Quantity:
1 mg
Unit Size:
1mg
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Product Code. 11559051

Brand: Invitrogen™ RP75738

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This item is not returnable. View return policy

Description

Recombinant Protein

RP-75738 contains purified recombinant human TNF alpha protein with an N-terminal hexahistidine tag. RP-75738 may be used as a positive control in many immunological assays.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P01375
Concentration 0.65 mg/mL
For Use With (Application) Control, Western Blot
Formulation 20 mM tris HCl with 50% glycerol and no preservative; pH 8
Gene ID (Entrez) 7124
Name Human TNF-alpha
pH Range 8
Quantity 1 mg
Source E. coli
Immunogen N/A
Regulatory Status RUO
Gene Alias APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1 F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Common Name TNF alpha
Gene Symbol TNF
Conjugate Unconjugated
Species E. coli
Recombinant Recombinant
Protein Tag His-tag
Sequence Amino acids Val77-Leu233 containing an N-terminal His-tag
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Protein Subtype Recombinant
Purity or Quality Grade >95%, by SDS-PAGE under reducing conditions
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