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Invitrogen™ Human Siglec-2 (CD22) His-tag, Recombinant Protein

HEK293 cells Recombinant Protein

670.00 NOK - 2300.00 NOK

Specifications

Accession Number P20273
For Use With (Application) Control, ELISA, Immunohistochemistry, Western Blot
Formulation PBS with 0.02% Tween 80, 5% mannitol, 5% trehalose and no preservative
Gene ID (Entrez) 933
Name Human Siglec-2 (CD22) His-tag
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17174273
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Invitrogen™
A42609
50 μg
2300.00 NOK
50µg
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17164273
View Documents Promotion Details
Invitrogen™
A42608
5 μg
670.00 NOK
5µg
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»
Estimated Shipment: 02-05-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
Description

Description

CD22 (BL-CAM) is a type 1 integral membrane glycoprotein with molecular weight of 130 to 140 kDa. CD22 is expressed in both the cytoplasm and cell membrane of B-lymphocytes. CD22 antigen appears early in B-cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Unlike other B-cell markers, CD22 membrane expression is limited to the late differentiation stages comprised between mature B cells (CD22+) and plasma cells (CD22-), and may thus prove useful in phenotyping mature leukemias. CD22 is also strongly expressed in hairy cell leukemia. CD22 preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. CD22 is also strongly expressed in hairy cell leukemia. CD22 is also positive in diffuse large B-cell lymphoma and nodular lymphocyte predominance Hodgkin’s lymphoma, but negative in classical Hodgkin’s lymphoma.
Specifications

Specifications

P20273
PBS with 0.02% Tween 80, 5% mannitol, 5% trehalose and no preservative
Human Siglec-2 (CD22) His-tag
-20°C
<1 EU/μg
CD22
Unconjugated
Lyophilized
Control, ELISA, Immunohistochemistry, Western Blot
933
HEK293 cells
RUO
A530093D23; B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; Cd22; CD22 antigen; CD22 molecule; FLJ22814; Leu-14; Lyb8; Lyb-8; MGC130020; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2; Siglec2; SIGLEC-2; T-cell surface antigen Leu-14
Human
Recombinant
≥ 95%
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