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Invitrogen™ Human E-selectin (CD62E) Recombinant Protein

Product Code. 11554231
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Quantity:
1 mg
Unit Size:
1mg
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Product Code. 11554231

Brand: Invitrogen™ RP75541

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This item is not returnable. View return policy

Description

Recombinant Protein

This product contains purified recombinant human e-Selectin protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays.

Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signaling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P16581
Concentration 0.105 mg/mL
For Use With (Application) Control, Western Blot
Formulation 0.02 M tris HCl with 100 mM NaCl, 1 mM EDTA, 50% glycerol and no preservative; pH 8
Gene ID (Entrez) 6401
Name Human E-selectin (CD62E)
Quantity 1 mg
Source E. coli
Immunogen N/A
Regulatory Status RUO
Gene Alias CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell
Common Name E-selectin (CD62E)
Gene Symbol SELE
Conjugate Unconjugated
Species E. coli
Recombinant Recombinant
Protein Tag His-tag
Sequence Amino acids Asn179- Leu557 containing an N-terminal His-tag
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Protein Subtype Recombinant
Purity or Quality Grade >95%, by SDS-PAGE under reducing conditions
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