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ACROBiosystems Human B7-H2 / ICOSLG Protein, Fc Tag

Brand:  ACROBiosystems B72-H5254-100ug

Additional Details : Weight : 0.00010kg

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Product Code. 16447179

  • 3799.50 NOK / 100µg
Estimated Shipment: 16-01-2023
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Description

Description

ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 53.1 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Specifications

Specifications

NP_056074.1
53.1 kDa
100 µg
Asp 19 - Ser 258
ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,ICOSL,LICOS,ICOS ligand
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human B7-H2, Fc Tag (B72-H5254) is expressed from human 293 cells (HEK293). It contains AA Asp 19 - Ser 258 (Accession # O75144-1).
-20°C
B7-H2
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
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