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HLA class I (HLA-C) Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 15777-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16885104

  • 3468.15 NOK / 150µL
Estimated Shipment: 22-12-2022
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Description

Description

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.
Specifications

Specifications

HLA class I (HLA-C)
Polyclonal
Unconjugated
HLA-C
D6S204, HLA C, HLA Cw, HLA Cw12, HLA JY3, HLAC, HLA-C, HLC C, MHC class I antigen Cw*7, PSORS1
Rabbit
Antigen Affinity Chromatography
RUO
3107
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
0.27 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P30508
HLA-C
HLA class I (HLA-C) Fusion Protein Ag8461
150 μL
Primary
Human
Antibody
IgG
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