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GILZ Monoclonal Antibody (CFMKG15), eBioscience™, Invitrogen™

Rat Monoclonal Antibody

920.00 NOK - 2590.00 NOK

Specifications

Antigen GILZ
Clone CFMKG15
Concentration 0.5 mg/mL
Classification Monoclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15297347
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Affymetrix eBioscience
14-4033-82
100 μg
2590.00 NOK
100µg
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15287347
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Affymetrix eBioscience
14-4033-80
25 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: GILZ is a leucine-zipper-containing protein that is induced by glucocorticoids. It is expressed in mast cells, monocytes, macrophages, dendritic cells, and T cells. GILZ has been shown to inhibit production of IL-2 as well as TCR-driven upregulation of FasL. GILZ mediates these changes in transcription, at least in part, by inhibiting DNA-binding of the transcription factors AP-1 and NF-kappaB. GILZ has also been shown to mediate anti-inflammatory signals in macrophages and dendritic cells by interfering with NF-kappaB-mediated signaling. Although GILZ has been reported to localize to the nucleus, more recent reports as well as testing at eBioscience have observed predomitly cytoplasmic staining. Applications Reported: This CFMKG15 antibody has been reported for use in intracellular staining followed by flow cytometric analysis, immunoblotting (WB), and immunocytochemistry. (Fluorochrome conjugated CFMKG15 is recommended for use in intracellular flow cytometry.). Applications Tested: This CFMKG15 antibody has been tested by western blot analysis of dexamethasone-treated mouse thymocytes. CFMKG15 recognizes endogenous mouse GILZ with an approximate molecular weight of 14 kDa; a non-specific band of approximately 95 kDa is also observed. CFMKG15 also recognizes endogenous human GILZ in dexamethasone-treated peripheral blood mononuclear cells, with an approximate molecular weight of 14 kDa; non-specific bands may also appear at approximately 33 kDa and 95 kDa.

The TSC22 domain family member 3 protein (TSC22D3) is a leucine zipper protein that functions as a transcriptional regulator. The expression of TSC22D3 is stimulated by glucocorticoids and IL-10 and is thought to play a key role in the anti-inflammatory and immunosuppressive effects of these molecules. TSC22D3 can physically interact with and inhibit the activities of key inflammatory signaling mediators such NF-Kappa-B and AP-1. TSC22D3 functions as a transcriptional co-activator for various nuclear receptors and NF-Kappa-B. It has also been shown to be involved in the differentiation of mesenchymal stem cells towards osteoblasts and bone formation.
Specifications

Specifications

GILZ
0.5 mg/mL
Unconjugated
Rat
Human, Mouse
14605, 1831
IgG2a κ
Affinity chromatography
Antibody
CFMKG15
Monoclonal
Liquid
RUO
Q99576, Q9Z2S7
TSC22D3
Primary
4° C
TSC22D3
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only.