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Invitrogen™ GeneArt™ Platinum™ Cas9 Nuclease (3 µg/µL)
Maximum efficient, the Cas9 RNP complex minimizes off-target cleavage compared to vector-based systems.
Brand: Invitrogen™ B25641
Additional Details : Weight : 0.00010kg
Alert:
For research use only. Not for use in diagnostic procedures.
Includes: 1 vial GeneArt Platinum Cas9 Protein
Description
Maximum efficient, the Cas9 RNP complex minimizes off-target cleavage compared to vector-based systems.GeneArt Platinum Cas9 Nuclease is the recombinant Streptococcus pyogenes Cas9 (wt) protein purified from E. coli that can be used for genome editing with CRISPR technology. Cas9 protein forms a very stable ribonucleoprotein (RNP) complex with the guide RNA (gRNA) component of the CRISPR/Cas9 system. The Cas9 RNP complex can act immediately once it enters the cell since there are no requirements for transcription or translation as with vector- or mRNA-based systems. Additionally, the Cas9 RNP complex is rapidly cleared from the cell minimizing the chance of off-target cleavage when compared to other systems (Kim, et al. 2014). Incorporation of a nuclear localization signal (NLS) aids delivery to the nucleus, thus increasing the rate of genomic DNA cleavage.
GeneArt Platinum Cas9 Nuclease features include:
- Streamline cell engineering by eliminating transcription and translation in the cell
- Eliminate time consuming cloning steps
- Minimize off-target cleavage due to rapid clearance of the protein complex from the cell
Certifications
CoA
Compliance
CoA
Recommended Storage
Store at -5 to -30°C
Specifications
1 vial of GeneArt platinum Cas9 protein. Store at -5 to -30°C | |
GeneArt™ Platinum™ Cas9 nuclease | |
Genetic Disease Research |
GeneArt™ Platinum™ Cas9 Nuclease, 75μg, 3μg/μL Concentration, –5 to –30°C Storage Temperature, DNA Replication and Repair Research Category, For Research Use Only, Dry Ice Shipping Condition | |
75 μL, 75 μg | |
3μg/μL |