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FOXP3 Mouse anti-Human, Mouse, Clone: eBio7979, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-7979-80

Additional Details : Weight : 0.01000kg

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Product Code. 15268087

  • 1238.00 NOK / 25µg


Estimated Shipment date
from Supplier 03-07-2019
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Description

Description

2 μm post- manufacturing filtered. FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
Specifications

Specifications

Foxp3
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q9BZS1, Q99JB6
AIID, DIETER, Forkhead box P3, foxp3, IPEX, JM2, PIDX, SCURFIN, XPID
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse
Western Blot
eBio7979
Unconjugated
FOXP3
Liquid
FOXP3
IgG1
25 μg
4° C
Primary
20371, 50943
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