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FDC Monoclonal Antibody (CNA.42), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9968-82

1326.73 NOK valid until 2024-03-29
Use promo code "21615" to get your promotional price.



Additional Details : Weight : 0.01000kg

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Product Code. 15208297

  • 1990.00 NOK / 100µg
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Description

Description

Description: The monoclonal antibody CNA.42 recognizes a unique carbohydrate epitope found on follicular dendritic cells (FDCs) from a variety of species. FDCs are large cells in germinal centers (GCs) of primary and lymphoid tissues. They present non-processed antigen and switch off apoptosis of B cells through a selection process resulting in selection of memory B cells. FDCs express many B cell markers such as CD21 (long isoform), CD23 and CD35. A role for FDCs as been shown in various infectious diseases such as AIDS and transmissible spongiform encephalitis. Staining with this CNA.42 monoclonal antibody is mainly restricted to the plasma membrane but in limited cases may also be cytoplasmic (as seen in mast cells). This monoclonal has been shown to be a useful reagent for both flow cytometry and IHC analysis. Applications Reported: This CNA.42 antibody has been reported for use in flow cytometric analysis, immunoblotting (WB), and immunohistochemistry on frozen and formalin-fixed paraffin embedded tissue sections. Applications Tested: This CNA.42 antibody has been tested by flow cytometric of a human cell line and western blotting. This can be used at less than or equal to 0.5 μg per million cells in a 100 μL total staining volume or 2 μg/mL (for western blotting). The antibody has also been tested by immunohistochemistry on formalin-fixed paraffin embedded human tonsil using high pH antigen antigen retrieval.

FDCs are large cells in germinal centers (GCs) of primary and lymphoid tissues. They present non-processed antigen and switch off apoptosis of B cells through a selection process resulting in selection of memory B cells. FDCs express many B cell markers such as CD21 (long isoform), CD23 and CD35. A role for FDCs as been shown in various infectious diseases such as AIDS and transmissible spongiform encephalitis.
Specifications

Specifications

FDC
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Mouse
100 μg
Primary
4° C
Liquid
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
CNA.42
Unconjugated
FDC
Affinity chromatography
RUO
Human
Antibody
IgM
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