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EIF2AK2 Mouse anti-Human, Clone: 2A8A4, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66646-1-IG-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16888715

  • 1281.92 NOK / 20µL
Estimated Shipment: 20-12-2022
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Description

Description

This antibody is specific to EIF2AK2.

PKR is a 68 kDa protein and an IFN-induced serine/threonine protein kinase consisting of two N-terminal RNA-binding regulatory domains and a functional C-terminal serine/threonine protein kinase domain. Activated by dsRNA produced during viral infections, PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. Upon activation, PKR gets autophosphorylated and catalyzes the phosphorylation of elF2 alpha subunit, which leads to an inhibition of protein synthesis. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & maligcy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.
Specifications

Specifications

EIF2AK2
Monoclonal
1 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P19525
EIF2AK2
EIF2AK2 Fusion Protein Ag13010
20 μL
Primary
Human
Antibody
IgG1
Immunohistochemistry (Paraffin), Western Blot
2A8A4
Unconjugated
EIF2AK2
eIF 2A protein kinase 2, EIF2AK1, EIF2AK2, P1/eIF 2A protein kinase, p68 kinase, PKR, PRKR, Protein kinase RNA activated
Mouse
Protein G
RUO
5610
-20°C
Liquid
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SDS
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