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Ea52-68 peptide bound to I-Ab Monoclonal Antibody (eBioY-Ae (YAe, Y-Ae)), Biotin, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

930.00 NOK - 2915.00 NOK

Specifications

Antigen Ea52-68 peptide bound to I-Ab
Clone eBioY-Ae (YAe, Y-Ae), Y-Ae)
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15259839
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Affymetrix eBioscience
13-5741-81
50 μg
930.00 NOK
50µg
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Estimated Shipment: 10-04-2024
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15269839
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Affymetrix eBioscience
13-5741-82
100 μg
1752.00 NOK
100µg
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In Stock
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15279839
View Documents Promotion Details
Affymetrix eBioscience
13-5741-85
500 μg
2915.00 NOK
500µg
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Estimated Shipment: 08-05-2024
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Description

Description

Description: The Y-Ae antibody reacts with a class II major histocompatibility complex (MHC) self Ea peptide (peptide 52-68) bound to I-Ab molecules. The Y-Ae antibody detects a determit expressed on a subset of class II I-Ab molecules in strains that also express class II I-Eb. This determit is expressed on peripheral B cells and on cells in the thymic medulla, but not thymic cortical epithelium. In addition to B cells, the Y-Ae determit is expressed at comparable levels on other antigen presenting cells, including macrophages and dendritic cells. The antibody does not react with invariant chain-associated class II MHC complexes. The reactivity of the Y-Ae antibody is MHC-restricted. The Y-Ae antibody was generated by immunization of [B10.MBR x B10.D2]F1 recipients with B10A(5R) LPS blasts. In this strain combination, there is incompatibility for I-Ab and I-Eb molecules. The antibody reacts with 10-15% of surface I-Ab molecules in strains that also express surface I-Eb molecules (e.g., strains B10.A(5R) and B10.A(3R)). The antibody does not react with I-A molecules in strains that have a non-functional I-E (a chain) gene (e.g., strains B6 and B10), nor with mutant I-A molecules (e.g., (B6.c-H-2bm-12 x A.TFR5)F1), nor with any other strain tested. The Y-Ae antibody recognizes an Ea peptide (Ea 52-68) bound to I-Ab molecules, but not to Ea 52-68 peptide bound to I-Ak or I-Abm-12 molecules.

MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II.
Specifications

Specifications

Ea52-68 peptide bound to I-Ab
0.5 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
Abeta; AI845868; H-2 class II histocompatibility antigen, A beta chain; H-2Ab; H2-Ab; H2-Ab1; H2Eb; H-2Eb; H2-iabeta; histocompatibility 2, class II antigen A, beta 1; Ia2; Ia-2; Ia4; Ia-4; IAb; I-Abeta; major histocompatibility complex class II beta chain; MGC163794; MGC163796; MHC class II antigen A beta; MHC class II H2-IA-beta-psi; response to metastatic cancers 1; Rmcs1
H2-Ab1
Primary
4° C, store in dark, DO NOT FREEZE!
H2-Ab1
eBioY-Ae (YAe, Y-Ae), Y-Ae)
Flow Cytometry
Biotin
Mouse
Mouse
P01921, P06342, P06343, P06344, P06345, P06346, P14483
14961
IgG2b
Affinity chromatography
Antibody
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