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CDCA2 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 17701-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16887634

  • 3468.15 NOK / 150µL
Estimated Shipment: 20-12-2022
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Description

Description

Cell division cycle associated 2 (CDCA2, Repo-Man) is a cell-cycle protein that recruits protein phosphatase 1 (PP1) to mitotic chromatin at anaphase onset, which is essential for cell proliferation. Carboxy-terminal phosphorylation of CDCA2 at Ser893 by Aurora B inhibits the protein and leads to diffuse localization during prometaphase and metaphase. Dephosphorylation of CDCA2 by PP2A is necessary for CDCA2/PP1 complex reformation. The CDCA2/PP1 complex is required for chromatin binding and dephosphorylation of histone H3 at Thr3, Ser10, and Ser28. The CDCA2/PP1 complex is also involved in nuclear envelope reformation during mitotic exit for proper progression through the M/G1 transition. The interaction of CDCA2 with importin beta and Nup153, which is required for nuclear envelope formation, is negatively regulated by CDK phosphorylation of the amino-terminal domain of CDCA2. CDCA2 may play a role in DNA repair as the release of CDCA2 from chromatin at sites of DNA damage promotes the activation of DNA damage response. These results imply that the CDCA2/PP1 complex may play a part in cancer progression. Research studies indicate that CDCA2 may serve as a prognostic marker, as increased CDCA2 expression is seen in a number of cancers, including melanoma, neuroblastoma tumors, squamous cell carcinoma, and synovial sarcomas.
Specifications

Specifications

CDCA2
Polyclonal
Unconjugated
CDCA2
CDCA2, Repo Man
Rabbit
Antigen Affinity Chromatography
RUO
157313
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunofluorescence, Immunocytochemistry
0.31 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q69YH5
CDCA2
CDCA2 Fusion Protein Ag11967
150 μL
Primary
Human
Antibody
IgG
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