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CD86 (B7-2) Mouse anti-Human, Biotin, Clone: IT2.2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-0869-80

Additional Details : Weight : 0.25000kg

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Product Code. 15269639

  • 738.00 NOK / 25µg


Estimated Shipment date
from Supplier 21-08-2019
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Description

Description

CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance. CD80 appears to play a role distinct from CD80 in T helper cell differentiation. CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms of CD86. Additional transcript variants have been described for CD86, but their full-length sequences have not been determined. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
Specifications

Specifications

CD86 (B7-2)
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P42081
B7-2, B7.2, B70, CD28LG2, LAB72, MGC34413, B-lymphocyte activation antigen B7-2, B-lymphocyte antigen B7-2, B7-2 antigen, BU63, CD28 antigen ligand 2
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
IT2.2
Biotin
CD86
Liquid
CD86
IgG2b, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
942
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For Research Use Only.