missing translation for 'onlineSavingsMsg'
Learn More

CD34, Biotin, clone: RAM34, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 13-0341-85

Additional Details : Weight : 0.25000kg

 View more versions of this product

Product Code. 15279529

  • 2400.00 NOK / 500µg


In Stock 4
Add to basket

Description

Description

Note: When staining with the RAM34 antibody an incubation time of 90 minutes is recommended to obtain the optimal signal to noise ratio. For more detailed information on staining with RAM34, please refer to Ema et al., listed under References. Filtration: 0.2 μm post-manufacturing filtered. CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
Specifications

Specifications

CD34
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q64314
Mucosialin, RP11-328D5.2, CD34 antigen, hematopoietic progenitor cell antigen CD34
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
RAM34
Biotin
Cd34
Liquid
Cd34
IgG2a, kappa
500 μg
4° C, store in dark, DO NOT FREEZE!
Primary
12490
Videos

For Research Use Only.