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CD324 (E-Cadherin) Rat anti-Canine, Human, Mouse, Clone: DECMA-1, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-3249-80

Additional Details : Weight : 0.01000kg

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Product Code. 15287337

  • 894.00 NOK / 25µg


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Description

Description

Applications Tested: This DECMA-1 antibody has been tested by western blot analysis of EDTA treated MDCK cell line. This can be used at less than or equal to 2 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintece of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
Specifications

Specifications

CD324 (E-Cadherin)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
F1PAA9, P12830, P09803
Arc-1, CD324, CDHE, ECAD, LCAM, UVO, CAM 120/80, E-Cadherin, cadherin 1, E-cadherin epithelial, cadherin-1, calcium-dependent adhesion protein, epithelial, cell-CAM 120/80, epithelial cadherin, uvomorulin, cadherin-E
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Canine, Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)
DECMA-1
Unconjugated
CDH1
Liquid
CDH1
IgG1, kappa
25 μg
4° C
Primary
12550, 442858, 999
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