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CD282 (TLR2) Monoclonal Antibody (6C2), Biotin, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

1080.00 NOK - 2835.00 NOK

Specifications

Antigen CD282 (TLR2)
Clone 6C2
Concentration 0.5 mg/mL
Applications Flow Cytometry, Immunohistochemistry (Frozen)
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15360090
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Affymetrix eBioscience
13-9021-82
100 μg
2835.00 NOK
100µg
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15350090
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Affymetrix eBioscience
13-9021-80
25 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The 6C2 monoclonal antibody reacts with mouse Toll-like receptor 2 (TLR2). Mouse TLR2 is expressed by the myeloid lineage, including macrophage and dendritic cells in splenocytes and the RAW264.7 cell line. To date, at least twelve members of the Toll family have been identified in human and mouse. This family of type I transmembrane proteins is characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. Two of these receptors, TLR2 and TLR4, are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation. TLR2 is expressed on the surface of cells and is responsible for distinguishing different pathogens. Applications Reported: This 6C2 antibody has been reported for use in flow cytometric analysis and immunohistochemical staining of frozen tissue sections. For optimal flow cytometry staining with this antibody, it is recommended that a directly conjugated 6C2 (FITC, PE, or Biotin) be used in combination with FcR blocking with anti-mouse CD16/CD32 (clone 93, cat.14-0161). Applications Tested: The 6C2 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL.

TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.
Specifications

Specifications

CD282 (TLR2)
0.5 mg/mL
Monoclonal
Liquid
RUO
Q9QUN7
Tlr2
Primary
4° C, store in dark, DO NOT FREEZE!
Tlr2
6C2
Flow Cytometry, Immunohistochemistry (Frozen)
Biotin
Rat
Mouse
24088
IgG2b κ
Affinity chromatography
Antibody
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