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CD279 (PD-1) Monoclonal Antibody (RMP1-14), eBioscience™, Invitrogen™
Rat Monoclonal Antibody
970.00 NOK - 2950.00 NOK
Specifications
Antigen | CD279 (PD-1) |
---|---|
Clone | RMP1-14 |
Concentration | 0.5 mg/mL |
Applications | Flow Cytometry, Functional Assay |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15268307
|
Affymetrix eBioscience
14-9982-82 |
100 μg |
1572.00 NOK
100µg |
In Stock Log in to see stock. |
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15278307
|
Affymetrix eBioscience
14-9982-85 |
500 μg |
2950.00 NOK
500µg |
Estimated Shipment: 08-05-2024 Log in to see stock. |
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15258307
|
Affymetrix eBioscience
14-9982-81 |
50 μg |
This item is currently unavailable or has been discontinued. View the product page for possible alternatives. |
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Description
Description: This antibody reacts with mouse PD-1 (programmed death-1), a 55 kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Similar to J43, another mAb to mouse PD-1 (cat. 16-9985), RMP1-14 blocks the binding of both B7-H1-Ig and B7-DC-Ig to PD-1 transfectants. Applications Reported: The RMP1-14 antibody has been reported for use in flow cytometric analysis. (Please use Functional Grade purified RMP1-14, cat. 16-9982, in functional assays.). Applications Tested: The RMP1-14 antibody has been tested by flow cytometric analysis of 3 day Con A activated splenocytes. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "e;danger signals"e; such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.Specifications
CD279 (PD-1) | |
0.5 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 0.09% sodium azide; pH 7.2 | |
CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2 | |
Pdcd1 | |
Primary | |
4° C | |
Pdcd1 |
RMP1-14 | |
Flow Cytometry, Functional Assay | |
Unconjugated | |
Rat | |
Mouse | |
Q02242 | |
18566 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.