CD253 (TRAIL) Rat anti-Mouse, Clone: N2B2, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 14-5951-85
Additional Details : Weight : 0.01000kg
DescriptionApoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand) (6,7). TRAIL is a type II membrane protein and expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL3-6. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
|PBS with 0.09% sodium azide; pH 7.2|
|Apo2L (for Apo-2 Ligand), TNF-Related Apoptosis-Inducing Ligand, Tumor necrosis factor ligand, superfamily member 10, TRAIL protein, CD253 antigen, TN|
|Flow Cytometry, Functional Assay, Immunoprecipitation, Neutralization|
For Research Use Only.