missing translation for 'onlineSavingsMsg'
Learn More

CD141 Monoclonal Antibody (JAA17), APC, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

1446.00 NOK - 3305.00 NOK

Specifications

Antigen CD141
Clone JAA17
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
View More Specs

Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15742466
View Documents Promotion Details
Affymetrix eBioscience
17-1419-42
100 Tests
3305.00 NOK
Pack of 100
View alternative products
Save Up to 
»
Estimated Shipment: 14-05-2024
to see stock.
Please to purchase this item. Need a web account? Register with us today!
15732466
View Documents Promotion Details
Affymetrix eBioscience
17-1419-41
25 Tests This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A View alternative products
Save Up to 
»
Description

Description

This JAA17 monoclonal antibody recognizes human CD141 also known as thrombomodulin, fetomodulin, or BDCA-3. CD141 is a type I membrane receptor that binds and allosterically activates thrombin. The resulting complex cleaves protein C and the Thrombin Activatable Fibrinolysis Inhibitor (TAFI), initiating an important anticoagulant and anti-fibrinolytic pathway. Soluble thrombomodulin is constitutively present in the serum at a very low level and can be upregulated during inflammation. The anti-inflammatory activity of thrombomodulin results from its ability to block the highly pro-inflammatory activity of thrombin. Thrombomodulin prevents chemotaxis and binding of granulocytes to activated endothelium and inhibits activation of eosinophils and mast cells thereby reducing inflammation. Mutations in the CD141 gene result in thromboembolic disease, also known as inherited thrombophilia. Although expressed across many tissues and cell types, its highest expression has been reported on the luminal surface of vascular endothelial cell. In the immune system the highest expression can be observed on myeloid cells, including dendritic cells, macrophages and blood monocytes. In humans, CD141 is commonly used as a marker of cross-presenting dendritic cells in both lymphoid and non-lymphoid tissues. Retinoic acid has been shown to upregulate CD141 expression on human monocyte-derived dendritic cells and primary human dendritic cells.

CD141 Monoclonal antibody specifically detects CD141 in Human samples. It is validated for Flow Cytometry.
Specifications

Specifications

CD141
5 μL/Test
Monoclonal
Liquid
RUO
P07204
THBD
Primary
4° C, store in dark, DO NOT FREEZE!
THBD
JAA17
Flow Cytometry
APC
Mouse
Human
7056
IgG2a κ
Affinity chromatography
Antibody
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only