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CD127 Monoclonal Antibody (eBioRDR5), Super Bright™ 600, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

1642.00 NOK - 3770.00 NOK

Specifications

Antigen CD127
Clone eBioRDR5
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
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Product Code Brand Quantity Price Quantity & Availability  
15792486
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Affymetrix eBioscience
63-1278-42
100 Tests
3770.00 NOK
Pack of 100
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15782486
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Affymetrix eBioscience
63-1278-41
25 Tests This item is currently unavailable or has been discontinued.
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Description

Description

The eBioRDR5 monoclonal antibody reacts with human CD127 (Interleukin-7 Receptor alpha). CD127 complexes with CD132, also known as the common gamma chain (gamma c), to form the multi-functional IL-7 receptor (IL-7R). CD127 is a type I glycoprotein with a molecular weight of 75-80 kDa and is expressed by immature B cells through the early pre-B stage, by thymocytes during several stages of their development, and on most mature T cells, with transient down-regulation upon activation. Binding of IL-7 results in signal transduction which occurs through several tyrosine kinase pathways including the Jak/STAT pathway. IL-7 is indispensible for the development of lymphocytes, and the control of homeostatic proliferation of T-cells in the periphery. In addition, IL-7R signaling is know to be involved in the regulation of T cell receptor (TCR) locus rearrangement in gamma delta T cells. Interestingly, recently it has been demonstrated that CD127 expression is down-regulated on CD4+CD25+ regulatory T cells (T regs). While the co-expression of CD4 and CD25 has become widely used as an indicator of T regs, this method of identification may also include cells without suppressive activity.

CD127 Monoclonal antibody specifically detects CD127 in Human samples. It is validated for Flow Cytometry.
Specifications

Specifications

CD127
5 μL/Test
Monoclonal
Liquid
RUO
P16871
IgG1 κ
Affinity chromatography
Antibody
eBioRDR5
Flow Cytometry
Super Bright 600
Mouse
Human
3575
Primary
4° C, store in dark, DO NOT FREEZE!
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Documents

Product Certifications

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