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CD126 Monoclonal Antibody (47.7G7.1F2), PerCP-eFluor™ 710, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

3135.00 NOK

Specifications

Antigen CD126
Clone 47.7G7.1F2
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
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Products 1
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15599176
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Affymetrix eBioscience
46-1269-42
100 Tests
3135.00 NOK
100 tests
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Estimated Shipment: 10-04-2024
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Description

Description

Description: This monoclonal antibody 47.7G7.1F2 reacts with human CD126, also known as IL-6 receptor alpha. It associates with the gp130 chain to form the high-affinity receptor for IL-6. Although gp130 is ubiquitously expressed, CD126 is only found on mature T cells, activated B cells, macrophages, hepatocytes, and myeloma cells. Upon binding to IL-6, two heterotrimeric complexes of receptor and ligand associate into a hexamer and are then internalized, initializing Jak/STAT signaling pathways. IL-6 induces the proliferation and survival of T cells, Th2 differentiation, and acute-phase protein production in the liver. A soluble form of CD126 lacking the transmembrane domain is also present and can be generated by cleavage at the cell surface or alternative splicing. Soluble CD126 can bind IL-6 and activate cells expressing only gp130 through trans-presentation. Applications Reported: This 47.7G7.1F2 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 47.7G7.1F2 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.06 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

CD126 Monoclonal antibody specifically detects CD126 in Human samples. It is validated for Flow Cytometry.
Specifications

Specifications

CD126
5 μL/Test
Monoclonal
Liquid
RUO
P08887
IL6R
Primary
4° C, store in dark, DO NOT FREEZE!
IL6R
47.7G7.1F2
Flow Cytometry
PerCP-eFluor 710
Mouse
Human
3570
IgG1 κ
Affinity chromatography
Antibody
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