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CD126 Monoclonal Antibody (47.7G7.1F2), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
3135.00 NOK
Specifications
Antigen | CD126 |
---|---|
Clone | 47.7G7.1F2 |
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15599176
|
Affymetrix eBioscience
46-1269-42 |
100 Tests |
3135.00 NOK
100 tests |
Estimated Shipment: 10-04-2024 Log in to see stock. |
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Description
Description: This monoclonal antibody 47.7G7.1F2 reacts with human CD126, also known as IL-6 receptor alpha. It associates with the gp130 chain to form the high-affinity receptor for IL-6. Although gp130 is ubiquitously expressed, CD126 is only found on mature T cells, activated B cells, macrophages, hepatocytes, and myeloma cells. Upon binding to IL-6, two heterotrimeric complexes of receptor and ligand associate into a hexamer and are then internalized, initializing Jak/STAT signaling pathways. IL-6 induces the proliferation and survival of T cells, Th2 differentiation, and acute-phase protein production in the liver. A soluble form of CD126 lacking the transmembrane domain is also present and can be generated by cleavage at the cell surface or alternative splicing. Soluble CD126 can bind IL-6 and activate cells expressing only gp130 through trans-presentation. Applications Reported: This 47.7G7.1F2 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 47.7G7.1F2 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.06 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
CD126 Monoclonal antibody specifically detects CD126 in Human samples. It is validated for Flow Cytometry.Specifications
CD126 | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
P08887 | |
IL6R | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
IL6R |
47.7G7.1F2 | |
Flow Cytometry | |
PerCP-eFluor 710 | |
Mouse | |
Human | |
3570 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.