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CD122 Monoclonal Antibody (5H4), Biotin, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

952.00 NOK - 2725.00 NOK

Specifications

Antigen CD122
Clone 5H4
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15279699
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Affymetrix eBioscience
13-1221-81
50 μg
952.00 NOK
50µg
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Estimated Shipment: 08-05-2024
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15289699
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Affymetrix eBioscience
13-1221-82
100 μg
1774.00 NOK
100µg
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15299699
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Affymetrix eBioscience
13-1221-85
500 μg This item is currently unavailable or has been discontinued.
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Description

Description

Description: The 5H4 antibody reacts with mouse CD122, the 90-110 kDa interleukin-2 receptor beta chain. CD122 is expressed by NK cells and some T cells in the periphery and is upregulated by activation. CD122 associates with CD25 and CD132 (common gamma chain) to form the high affinity IL-2 receptor. Binding of IL-2 to CD122 is not inhibited by the 5H4 antibody. Applications Reported: The 5H4 antibody has been reported for use in flow cytometric analysis. Applications Tested: The 5H4 antibody has been tested by flow cytometric analysis of resting and activated mouse splenocytes. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

CD122 (Interleukin 2 receptor) is involved in T cell-mediated immune responses, primarily expressed in the hematopoietic system and is present in 3 forms. The low affinity form of CD122 is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from CD122. The protein encoded by the CD122 gene represents the beta subunit and is a type I membrane protein. Diseases associate with CD122 protein dysfunction include oligoarticular juvenile idiopathic arthritis and rheumatoid factor negative juvenile idiopathic arthritis.
Specifications

Specifications

CD122
0.5 mg/mL
Monoclonal
Liquid
RUO
P16297
Il2rb
Primary
4° C, store in dark, DO NOT FREEZE!
Il2rb
5H4
Flow Cytometry
Biotin
Rat
Mouse
16185
IgG2a κ
Affinity chromatography
Antibody
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