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CD11b Rat anti-Mouse, Functional Grade, Clone: M1/70, eBioscience™

Rat Monoclonal Antibody

1212.00 NOK - 3675.00 NOK

Specifications

Antigen CD11b
Clone M1/70
Target Species Mouse
Conjugate Functional Grade
Isotype IgG2b, kappa
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15248377 Affymetrix eBioscience
16-0112-82
100 μg 1212.00 NOK
100µg View alternative products
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In Stock 3
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15258377 Affymetrix eBioscience
16-0112-85
500 μg 2190.00 NOK
500µg View alternative products
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In Stock 1
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15268377 Affymetrix eBioscience
16-0112-86
1 mg 3675.00 NOK
1mg View alternative products
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Estimated Shipment date
from Supplier 01-08-2019
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Description

Description

Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
Specifications

Specifications

CD11b
Mouse
IgG2b, kappa
Monoclonal
Liquid
Antibody
4° C
M1/70
Functional Grade
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Neutralization
Primary
Monoclonal
PBS with no preservative; pH 7.2
RUO

For Research Use Only.