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c-Met Rat anti-Mouse, Clone: eBioclone 7, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-8854-80

Additional Details : Weight : 0.01000kg

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Product Code. 15288097

  • 730.00 NOK / 25µg


Estimated Shipment date
from Supplier 01-08-2019
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Description

Description

Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
Specifications

Specifications

c-Met
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P16056
AUTS9, HGFR, RCCP2, c-Met
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
eBioclone 7
Unconjugated
Met
Liquid
Met
IgG1, kappa
25 μg
4° C
Primary
17295
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