PMP70 Polyclonal Antibody, Biotin, Invitrogen™

Description

PMP70 Antibody, Biotin conjugate, PA1-1650, from Invitrogen™. Species Reactivity: Human, Mouse, Rat; Applications: Flow Cytometry, Western Blot.

Peroxisomes are single membrane organelles which are involved with many important biochemical pathways and are found in almost all eukaryotic cells. Various toxins including, phenols, alcohols, and aldehydes are targeted for modification by peroxisomes. Long chain fatty acid metabolism via beta-oxidation is also mediated by this organelle. Loss of peroxisomal functions may result in diseases such as Zellweger syndrome, hyperpipecolic acidemia, neonatal adrenoleukodystrophy, and infantile Refsum’s disease. Peroxisomal membrane protein 70 (PMP70) is an abundant, integral membrane protein of the peroxisome. This protein is induced by treatment with hypolipidemic agents in parallel with peroxisome proliferation and stimulation of the peroxisomal beta-oxidation enzymes.
Host Species: Rabbit
Cross Reactivity: Human, Mouse, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to residues C N(644) Y E F K K I T E D T V E F G S(659) of rat PMP70.
Formulation: 100μg purified antibody (1mg/mL) in PBS with 1mg/mL BSA and 0.05% sodium azide
Synonyms: Peroxisomal Membrane Protein 70, 70 kDa peroxisomal membrane protein
Uniprot Accession: P16970, P28288, P55096
Entrez GeneID: 19299, 25270, 5825
Gene Symbol: ABCD3
PA1.1-650 detects peroxisomal membrane protein 70 from mouse, rat and human tissues. PA1.1-650 has been successfully used in Western blot, ICC/IF and FACS procedures. By Western blot, this antibody detects an ∽70 kDa protein representing PMP70 from mouse kidney protein extracts. The PA1.1-650 immunogen is a synthetic peptide corresponding to residues C N(644) Y E F K K I T E D T V E F G S(659) of rat PMP70. This sequence is completely conserved in mouse PMP70 and differs from human PMP70 by a single amino acid substitution. PA1.1-650 immunizing peptide (Cat. # PEP-038) is available for use in neutralization and control experiments.