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Phospho-GAB1 (Tyr627) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA538133
Additional Details : Weight : 0.00900kg
Description
Gab 1 (GRB2-associated binder 1), one such member of the IRS family, plays an important role in cellular growth response, transformation and apoptosis. Gab 1 is a multi-substrate docking protein that functions downstream in the signaling pathways of different receptor kinases, including EGFR. Gab1 is tyrosine phosphorylated normally in response to insulin and consequently enhances phosphatidylinositol 3- kinase (PI3K) binding. In response to osmotic shock, tyrosine-phosphorylated Gab 1 (p-Gab 1) also binds and activates phosphatidylinositol 3-kinase, suggesting that Gab 1 is the major site for PI3K recruitment following osmotic shock stimulation.Specifications
| Phospho-GAB1 (Tyr627) | |
| Polyclonal | |
| Unconjugated | |
| GAB1 | |
| GAB1, GRB2-associated-binding protein 1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 14388, 2549 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q13480, Q9QYY0 | |
| GAB1 | |
| A synthetic phosphopeptide derived from human Gab1 around the phosphorylation site of Tyr627 (V-E-YP-L-D) | |
| 100 μg | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |