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Phospho-BLNK (Tyr96) Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA538357
Additional Details : Weight : 0.00900kg
Description
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR- mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.Specifications
Phospho-BLNK (Tyr96) | |
Polyclonal | |
Unconjugated | |
BLNK | |
B-cell linker protein, LY57, SLP-65, SLP65 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
17060, 29760 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q8WV28, Q9QUN3 | |
BLNK | |
A synthetic phosphopeptide derived from human BLNK around the phosphorylation site of Tyr96 (D-S-YP-E-P) | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |