missing translation for 'onlineSavingsMsg'
Learn More

CD28 Mouse anti-Human, Functional Grade, Clone: CD28.6, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-0288-85

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15268417

  • 2705.00 NOK / 500µg


In Stock 5
Add to basket

Description

Description

Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. CD28 is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes. Moreover, CD28 is the critical T cell costimulatory receptor that provides the cell the important second activation signal by binding CD80 and CD86 which are expressed by antigen presenting cells. In addition to its co-stimulation role, CD28 functions by preventing T cells from entering an anergic-hyporesponsive state or from undergoing premature apoptotic cell death. In murine peripheral lymphoid organs and in the blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+ and CD4+8+ cells, and on CD4-8- cells that express alpha/beta and gamma/delta TCR. The level of CD28 on mature CD4+ and CD8+ alpha/beta TCR+ thymocytes is two- to fourfold lower than on the immature cells. Diseases associated with CD28 dysfunction include mycosis fungiodes and Sezary’s Disease.
Specifications

Specifications

CD28
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
P10747
MGC138290, Tp44, CD28 antigen, T-cell-specific surface glycoprotein CD28
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Functional Assay, Neutralization, Western Blot
CD28.6
Functional Grade
CD28
Liquid
CD28
IgG2a, kappa
500 μg
4° C
Primary
940
Videos

For Research Use Only.